LPPEPTIDE | DSIP 5mg | 5mg x 10 vials | 10 vials / box

What is DS5?

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (9 amino acids) first isolated from rabbit brain tissue and studied for its effects on sleep architecture and stress modulation. Research indicates DSIP may promote delta-wave (slow-wave) sleep, modulate cortisol and ACTH levels, and exhibit stress-protective properties. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for clear insulin-syringe measurements.

Research context

DSIP (Delta Sleep-Inducing Peptide) is dosed at 100 mcg–300 mcg daily via subcutaneous injection in educational protocols, usually before bedtime. A 5 mg vial reconstituted with bacteriostatic water yields about 1.67 mg/mL. This information is for research and educational use only.

Reference literature focus

DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) was first characterized in 1977 as a sleep-modulating factor isolated from rabbit brain. Mechanistic studies suggest DSIP may influence sleep by modulating GABAergic transmission and interacting with opioid receptor systems. Research indicates it can increase delta-wave (slow-wave) sleep duration without significantly altering REM sleep architecture. Beyond sleep, DSIP has demonstrated stress-protective and adaptogenic properties in various models, potentially through modulation of the hypothalamic-pituitary-adrenal axis.

LPPeptide handling reference

Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL concentration. Typical daily range: 100–300 mcg once daily (gradual titration); advanced up to 500 mcg. Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 mcg on a U-100 insulin syringe.

Storage

Lyophilized: Store at −20 °C (−4 °F) in dry, dark conditions; minimize moisture exposure. Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); use within ~4 weeks and avoid freeze–thaw. Allow vials to reach room temperature before opening to reduce condensation uptake

Safety observations

May promote deeper, more restorative slow-wave sleep and improve subjective sleep quality. Some studies indicate DSIP does not induce pharmacological tolerance with continued use. Generally well tolerated in human studies; occasional mild injection-site reactions may occur with subcutaneous administration. Limited long-term safety data; periodic breaks are recommended as a precaution.

Contraindications

Research suggests potential stress-protective and anxiolytic-like effects. Limit blue light exposure and stimulants (caffeine, nicotine) in the hours before bed.

Certificate of Analysis

Each LPPeptide lot should be confirmed against current batch documentation before shipment or study use. This product page keeps DS5 visible so the SKU can be matched to the active COA.

Current catalog summary

- SKU: DS5 - Product: DSIP 10mg - Storefront specification: 5mg x 10 vials /box - LPPeptide reference specs: 5mg x 10 vials / 10mg x 10 vials - Listed box price: $60.00 USD - Reference: LPPeptide product knowledge record

Testing checklist

- Peptide identity or material identity - HPLC purity or assay result where applicable - Batch ID and test date - Sterility/endotoxin or accessory checks when applicable - Residual solvent and handling notes where applicable

Direct catalog supply

LPPeptide product pages use our own SKU, package, price, and stock data first. LPPeptide knowledge mapping adds compound education, handling notes, and specification checks while lot-specific editorial content is being prepared.

Lot-specific content

For final release decisions, use the current product record, COA, handling sheet, and research SOP as the highest-priority source for this page.